The film tells the story of three people for a year a son (Magimel) diagnosed with cancer, a mother (Deneuve) suffering from helplessness and a doctor (Cécile de France) to do her job One year and four seasons for these three characters to deal with the disease, to tame it, and to understand what it means to die while alive.
The adventure begins when the loving owners of three irresistible pets (Chance, a fun-loving American bulldog pup; Sassy, a hilarious Himalayan cat who lives up to her name; and Shadow, a wise old golden retriever) are forced to leave them in the temporary care of a friend who lives hundreds of miles away. But after several days, the worried animals begin to their family must be in trouble, so they decide to head for home. On their incredible journey across the ruggedly beautiful Sierras, they encounter unexpected surprises from man, beast, and nature alike.